This was a very preliminary study to see if certain treatments might be better with certain genetic tendencies. I don’t think they were even thinking about direct gene manipulation.

I think they wanted to know, with their current knowledge of gene loci that affect diabetes, could they predict who would become a diabetic, and could they predict it better than with the risk factors we already use for prediction?

If they could predict it better, then they would probably look at how those loci affect diabetes risk, find what these loci were doing to cause diabetes, and try to find medications that would specifically treat what those loci were doing.

However, they were unsuccessful in predicting diabetes better than known risk factors, so it is back to the drawing board.

But I’m a little confused. Is the idea here that there really would be genetic treatments? And at what point in the life stage would they be done?

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As one that has this disease, I’m a believer that it can be controlled by diet and exercise. The connections to genetics just help to make predictions a little easier, I’m sure a weather forecaster can get it right 50% of the time on an educated guess. All the risk factors just help the pros to get a little closer on diagnosis. With over 6 million undiagnosed cases of Type II in the US would seem to me that education should be pushed rather than genetics. The workload is already there.

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Little things done consistently (movement everyday, good food choices) can make a big difference.