|What is MGUS (monoclonal gammopathy of undetermined significance)?|
by James Hubbard, M.D., M.P.H.
Q. I need more explanation on my diagnosis. I had a serum immunofixation test and it came back with IgG-Lambda monoclonal gammopathy. I then did a 24-hour urine test. Now they say it's monoclonal gammopathy of undetermined significance. I was told to come back every six months for more blood work.
Could you please tell me more about this? Maybe even a good Web page or book I could read. Everything I have found says it's only an old person's disease; I am a healthy, active, 34-year-old mother.
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You mentioned that you've read people with MGUS are generally older. The risk of MGUS does go up with age. Most people who have it are over 50. I did find one article in the New England Journal of Medicine noting that 24 of the 1,384 patients in this particular study were under 40 years old.
It appears we need to learn a lot before we can take off the “undermined significance” part of the name.
Last updated and/or approved: October 2011. This general health-care information is not meant as individual advice. Please see our disclaimer.
written by Leigh Ann , October 12, 2010
Hi, Carl. Thank you for the question. You may find the PDF doc*ment at the following link, from Myeloma Canada, helpful:
It explains that myeloma can result in anemia (a symptom of which can be feeling very tired), and one treatment option is supplementation: "If your anemia is due to a change in your diet, eating a healthier diet or taking iron, vitamin B12 or
folic acid (folate) supplements may help. Always check with your doctor or pharmacist before taking any non-prescription, over-the-counter iron or vitamin supplement, or any herbal remedy. Some supplements or remedies can interact with prescription medications."
Hope this helps--and that you get your energy back soon.
Leigh Ann Otte
Managing Editor, MyFamilyDoctorMag.com
written by Carl Kiefer , October 07, 2010
I iwas just diagnosed with MGUS, will continue blood tests regularly. Told by Dr. to take vitamin B12 and Folic Acid. I am extremely tired all the time. Will the vitamins help?
written by kris , March 23, 2009
I was also diagnosed with MGUS (IGG) at the Mayo Clinic. Some people with MGUS DO have symptoms. I was told that my neurological symptoms are due to MGUS. There have been studies that confirm that MGUS does cause symptoms in some people. Do a search on MGUS with symptoms or Neurological symtoms and MGUS - you will find much information about this.
written by James Hubbard M.D. M.P.H. , March 04, 2009
If you continue your routine blood tests your doctor should be able to recognize any problems before you notice any symptoms
I know it is difficult, but worry and stress are not good. If you have not already, make an appointment specifically to talk to your doctor, questions and notes in hand.
Until more is found out, you will need the blood tests for a lifetime. Likely nothing will ever develop worse, but if it does, early recognition and treatment is essential to recovery.
Again, there are no warning signs or symptoms anywhere close to as early as an abnormal blood test.
what to look for
written by Becky , March 04, 2009
So I too have Igg Lambda monoclonal gammapathy, (MGUS)this is the same thing correct?
other than see my doctor every 6 months, what symptoms do I rule out and what symptoms may mean that I need to warn my doctor. I am lost please help me too.